If you haven’t heard about spermadine for longevity already, then now is the time to get acquainted with this super youth boosting compound. And yes, it does sound pretty odd, but don’t let the strange name discourage you. Spermadine is one of the most studied natural compounds in longevity science. The good news is, you can access pretty easily. Here’s what you need to know.
- 1 Why is it a hot topic in longevity science?
- 2 The link between longevity and spermadine
- 2.1 The 3 main things you need to know about how spermadine impacts aging
- 2.2 What foods are high in spermidine?
- 2.3 How to choose the right spermadine supplement?
- 2.3.1 here’s how
- 2.3.2 The bottom line
- 2.3.3 references
- 22.214.171.124 Lifespan: Spermadine: https://www.lifespan.io/news/a-summary-of-spermidine
- 126.96.36.199 Nature: https://www.nature.com/articles/s41598-022-08168-2
- 188.8.131.52 Minois N, Carmona-Gutierrez D, Madeo F: Polyamines in aging and disease. Age 2011;3:716-732. External ResourcesPubmed/Medline (NLM)Pucciarelli S, Moreschini B, Micozzi D, De Fronzo GS, Carpi FM, Polzonetti V, Vincenzetti S, Mignini F, Napolioni V: Spermidine and spermine are enriched in whole-blood of nona/centenarians. Rejuv Res 2012;15:590-595. External ResourcesPubmed/Medline (NLM)Crossref (DOI)Soda K, Kano Y, Sakuragi M, Takao K, Lefor A, Konishi F: Long-term oral polyamine intake increases blood polyamines concentrations. J Nutr Sci Vitaminol 2009;55:361-366. External ResourcesPubmed/Medline (NLM)Crossref (DOI)Soda K, Dobashi Y, Kano Y, Tsujinaka S, Konishi F: Polyamine-rich food decreases age-associated pathology and mortality in aged mice. Exp Gerontol 2009;44:727-732. External ResourcesPubmed/Medline (NLM)Crossref (DOI)Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López- Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G: Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J Cell Biol 2011;192:615-629. External ResourcesPubmed/Medline (NLM)Crossref (DOI) Minois N, Carmona-Gutierrez D, Bauer MA, Rockenfeller P, Eisenberg T, Brandhorst S, Sisgrist SJ, Kroemer G, Madeo F: Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways. Cell Death Dis 2012;3:e401. External ResourcesChoi YH, Park HY: Anti-inflammatory effects of spermidine in lipopolysaccharide-stimulated BV2 microglial cells. J Biomed Sci 2012;19:31. External ResourcesPubmed/Medline (NLM)Crossref (DOI)Paul S, Kang SC: Natural polyamine inhibits mouse skin inflammation and macrophage activation. Inflamm Res 2013;62:681-688. External ResourcesPubmed/Medline (NLM)Crossref (DOI)Vuohelainen S, Pirinen E, Cerrada-Gimenez M, Keinänen TA, Uimari M, Khomutov AR, Jänne J, Alhonen L: Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes. J Cell Mol Med 2010;14:1683-1692. External ResourcesPubmed/Medline (NLM)Crossref (DOI) Ishii I, Ikeguchi Y, Mano H, Wada M, Pegg AE, Shirahata A: Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells. Amino Acids 2012;42:619-626. External ResourcesPubmed/Medline (NLM)Crossref (DOI) Maccarrone M, Bari M, Battista N, Di Rienzo M, Falciglia K, Finazzi Agrò A: Oxidation products of polyamines induce mitochondrial uncoupling and cytochrome c release. FEBS Lett 2001;507:30-34. External ResourcesPubmed/Medline (NLM)Crossref (DOI)Bennetzen MV, Marino G, Pultz D, Morselli E, Faergeman NJ, Kroemer G, Andersen JS: Phosphoproteomic analysis of cells treated with longevity-related autophagy inducers. Cell Cycle 2012;11:1827-1840. External ResourcesPubmed/Medline (NLM)Crossref (DOI)Vellai T, Takács-Vellai K, Sass M, Klionsky DJ: The regulation of aging: does autophagy underlie longevity? Trends Cell Biol 2009;19:487-494. External ResourcesPubmed/Medline (NLM)Crossref (DOI) Stark F, Pfannstiel J, Klaiber I, Raabe T: Protein kinase CK2 links polyamine metabolism to MAPK signaling in Drosophila. Cell Signal 2011;23:876-882. External ResourcesPubmed/Medline (NLM)Crossref (DOI)
What is spermidine?
This polymine compound was discovered and named Despite its name, spermidine is not exclusively found in semen, but in all eukaryotic cells. The compound is naturally occurring and found in ribosomes and living tissues. spermidine plays a critical role in cell function and survival.
Why is it a hot topic in longevity science?
Studies show that polyamine levels decrease with age. . However, it’s only recently that the effect of polyamines, especially spermidine, on aging has been more fully interrogated.
Key benefits of spermadine
Reduces cancer risk
Studies found that eating a spermidine-rich diet could potentially reduce the risk of cancer-related mortality among humans. Spermidine can prevent liver fibrosis and hepatocellular carcinoma which are one of the most common causes of liver cancer.
It’s used in supplements which, when taken regularly, can have a significant impact on longevity.
Boosts your immune system
According to Nature“Spermidine treatment has been shown to prolong the life span of yeast, flies, worms, mammalian cells and mice3,4 and to lead to cardio protection3 and improved cognitive function5 in aging mice.”
Spermidine is also an important factor in the regulation of the immune system at various levels.
Protects against heart disease
If you take it regularly, spermidine can reduce your blood pressure levels. It will also lower your risk of cardiac hypertrophy, heart failure, and other cardiovascular diseases.
Autophagy is the main mechanism of action of spermidine effects on aging. It’s the recycling mechanism of the cell, allowing the destruction and re-use of unneeded or damaged molecules or whole organelles. A deficient autophagy has
been linked to many age-related diseases.
A system that breaks down waste inside cells and recycles cellular components. It is an important quality control mechanism for the mitochondria, the powerhouses of our cells.
The process allows damaged or defective mitochondria to be broken down and disposed of. The disposal of mitochondria is more tightly controlled than was before believed.
Combats neurodegenerative disease
Taking spermidine supplementally can reverse neuron damages caused by inflammation, oxidative stress, and ischemia.
As a result, it can decrease the risk of suffering neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease.
Alters Lipid metabolism
This has recently emerged as a strong regulator of health and lifespan. A dysfunction in lipid metabolism can trigger deleterious consequences on health and ultimately aging and lifespan. On the other hand, many mutations increasing lifespan have been associated with increased levels of stored lipids (TAG) and changes in lipid profiles (composition and saturation levels).
The involvement of spermidine in adipogenesis combined with our results showing that spermidine alters lipid profile in fruit flies makes lipid regulation a likely contributor for the effect of spermidine on aging.
Aging has been characterized by a chronic inflammation profile that leads to chronic damage to cells and is associated with many age-associated diseases. Polyamine levels generally increase with inflammation but whether they are more pro- or anti-inflammatory has been debated.
It seems that recent research shows that polyamines have mostly anti-inflammatory effects, some of them recently reviewed.
One study found that higher survival rates among humans were linked to increased spermidine intake through dietary sources such as supplementations. Importantly, Spermidine is vital to foster one’s cellular health and renewal, and as the cells are the body’s building blocks,
The 3 main things you need to know about how spermadine impacts aging
Getting older is a complex and multi-dimensional process. Aging is caused by many different interacting factors affecting all levels of the organism.
Spermadine has been shown to help in these 3 key areas
- Reducing the effects of sustained exposure to cellular stress,
- Addressing chronic inflammation and dysregulation of lipid metabolism
- Improving autophagy and boosting cell survival
What foods are high in spermidine?
The super compound is found in fresh green pepper, wheat germ, cauliflower, broccoli, mushrooms, and a variety of cheeses. Even higher amounts are found in soybean products such as natto, shitake mushrooms, amaranth grain and durian. This may explain why the Japanese have such good longevity: Eat like the Okinawans
Also many of these fruit and vegetables are common in a Mediterranean diet, which is also known to promote longevity.
- wheat germ
- Amaranth grain
- chick peas
- fresh green pepper
- Mushrooms (particularly shitake mushrooms)
- Green Tea
- Certain kinds of mature cheeses
- I am products
What about supplementation?
It’s most likely that we do not get enough of spermadine in our diet all the time. This is why you may consider a supplement to help increase your longevity.
The synthetic spermidine used in supplements is identical to the naturally occurring molecule.
The rise of the supplements market – manufactured products intended to supplement your diet – means that additional, complementary longevity options are available. Make sure you buy from a reputable source, laboratory which has GMP with other regulatory checks.
How to choose the right spermadine supplement?
Rules regarding supplementation vary by country. You will need to do some basic research on the regulations if you are living outside of the US or buying a non-US product. As a basic rule all supplements would be labeled with information regarding their manufacturing practices and identify which country they are produced in and are regulated by.
In the USA, you need to look for the USP or ConsumerLab label.
To ensure that a dietary supplement is of high quality and not contaminated or adulterated with other materials is to purchase products with labels indicating they have been tested by either the independent, nonprofit US Pharmacopoeial (USP) Convention Dietary Supplement Verification Program or ConsumerLab.com.
Purchase dietary supplements made in countries where there are regulations to protect consumers and rom established outlets.
Don’t buy blindly. Research a product before buying it and check reviews, especially the value of reporting use, as well as any bad reactions. You can also look at the About Herbs, website which also helps you understand ingredients and what to look out for.
If the research is anything to go by, spermadine is a super compound which will make a difference to how we age. By reducing the effects of sustained exposure to cellular stress, Addressing chronic inflammation and dysregulation of lipid metabolism and improving autophagy and boosting cell survival
If you are serious about aging well, then make sure you are getting enough of spermadine in your diet.