topical oral hyaluronic acid anti-aging study

A research team out of Italy, Carlomagno et al, recently published a study in Cosmetics evaluating the effectiveness of both external and internal use of hyaluronic acid as a treatment for skin aging.

According to Carlomagno et al, hyaluronic acid is naturally occurring in the skin but decreases with age. One study showed a 75-year-old person had less than a quarter of the naturally occurring hyaluronic acid as a 19-year-old person.

In the skin of the oldest subjects, hyaluronic acid is still present in the dermis but not in the epidermis, which may cause a loss of skin moisture.

“Hyaluronic acid has long been used for its anti-age properties, as an ingredient in both topical applications and food supplements,” Carlomagno et al said. “In this study, a novel sodium hyaluronate… was administered as an ingredient of a cosmetic product and as the main constituent of a food supplement to evaluate its efficacy in counteracting skin aging signs.”

Carlomango et al said the ingredient is similar to the hyaluronic acid already present in the skin.


The clinical study found both the skincare product and food supplement improved skin aging signs including skin hydration distribution, skin firmness, wrinkle depth and skin smoothness.

However, Carlomango et al said skin condition more significantly increased in the subjects who were being treated both orally and topically with the hyaluronic acid ingredient.

“The novelty of this clinical study also relies on the in and out approach, ie, a concomitant supply of the same active ingredient, hyaluronic acid, through two different routes: topical and oral,” Carlomango et al said.


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