Multi-component supplement may help post-COVID fatigue recovery: Data

Data published in Nutrients​ indicated that the combination of nine essential amino acids plus cysteine, malic, succinic, and citric acid, and vitamin B6 and B1 also improved the quality of life in people who have recovered from COVID-19.

The new study, performed by scientists from Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS in Rome, was only pilot scale and so additional, larger trials are necessary to validate the findings.

But despite this data being preliminary, the Rome-based scientists noted: “It is important to highlight that the assessment of nutritional status and the treatment with adequate multicomponent nutritional support is advised in all patients in the acute stage of COVID-19 and in the post-acute phase as well.”


While the list of symptoms associated with SARS-CoV-2 infection has changed depending on the specific virus variant, fatigue remains a constant issue for many people during and after infection.

“It has been clearly established that even twelve weeks after the onset of COVID-19, more than 50% of patients continued to suffer from fatigue and 15–20% still had smell disorders, distorted taste, and loss of appetite,” explained the Rome-based researchers.

“With the persistence of these conditions, it is important to advocate for specific nutritional assessment protocols and the prescription of multicomponent nutritional support.”

Study details

In order to examine if an oral nutritional supplement could improve outcomes, the researchers recruited 66 people who had recovered from COVID-19 but were still suffering symptoms of fatigue. Half of these people were assigned to the nutritional supplement, which consisted of 10 amino acids (Leucine, Lysine, Threonine, Isoleucine, Valine, Cysteine, Histidine, Phenylalanine, Methionine, Tryptophan), plus vitamins B6 and B1, plus malic, succinic, and citric acids. Another 33 people were recruited to act as controls (no intervention).


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