Researchers conducted a randomized controlled trial designed to determine the effect of Twin Precision Treatment technology (TPT) versus standard care (SC) on change in A1C and type 2 diabetes remission at 90-day intervals. The TPT intervention uses the Whole-Body Digital Twin Platform, with AI and Internet of Things, to integrate multi-dimensional data to give precision nutrition, sleep, activity, and breathing guidance via the TPT app and coaches.
Baseline mean age, diabetes duration, and A1C obtained in 319 patients were 45 years old (±9.7y), 3.9 years (±2.9 years), and 9% (±1.9%), respectively. Interim analysis of 262 patients (TPT n=199; SC n=63) who reached 180 days showed 94.9% (189/199) of TPT patients achieved an A1C less than 6.5% on no medications or metformin only; 83.9% (167/199) achieved diabetes remission based on ADA criteria. All nine insulin-using patients stopped insulin before 90 days. The TPT intervention in patients with type 2 diabetes allowed for significant reduction in A1C, diabetes remission (~84%), and improvement in multiple metabolic parameters at six months.
“Our results demonstrate the potential of Whole Body Digital Twin technology to change the conventional, medication-driven management of type 2 diabetes to achieving remission of type 2 diabetes with a life free of medication,” said Paramesh Shamanna, MD, lead author on the study. “The impact of the program on patient satisfaction, quality of life, and total cost of care is substantial and holds significant promise for large populations suffering from metabolic disease globally.”
Whole Body Digital Twin is a predictive model that provides individualized nutrition, sleep, activity, and breathing guidance to patients and their health care providers, with the potential to help reverse diabetes and metabolic diseases. The technology was built from thousands of data points collected daily via non-invasive wearable sensors, providing a personalized representation of each individual’s unique metabolism.
The authors note that future long-term studies are needed to support these initial findings.
Research presentation details:
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SOURCE American Diabetes Association