The symposium will highlight findings from a new study, Deciphering Longitudinal Cell Type-Specific Defects in Diabetes Pathogenesis, evaluating how type 2 diabetes ages the composition and gene regulatory programs of each cell type in human pancreatic islets using genomic profiling.
In the study, researchers completed genomic profiling of approximately 250,000 cells from 17 non-diabetic, 14 pre-diabetic, and 17 type 2 diabetic individuals, representing the largest single cell genomic analysis to date, both in number of cells studied and number of non – diabetic, pre-diabetic, and type 2 diabetic individuals. Findings showed that islets from type 2 diabetics contained significantly fewer insulin-producing beta cells and identified new genes that are mis-regulated.
“These findings help us to better understand what genes play a role in islet dysfunction, a major contributor to type 2 diabetes. These insights should better inform therapeutic targets so that we can better protect or fix insulin-producing beta cells of type 2 diabetic individuals ,” said Michael L. StitzelPhD, Associate Professor at The Jackson Laboratory for Genomic Medicine.
Novel Glucose Management
Findings were also presented from Untethering Diabetes through Innovative Engineering Evaluating micro-electromechanical systems, microfluidics and bio-sensing to achieve the goal of a painless, minimally invasive, low-cost, calibration-free, insulin pump-compatible CGM. The author will present a proposed solution for the unmet need for a painless, low-cost, disposable patch that can be adopted by Type I, and Type 2, and pre-diabetic individuals.
“A major goal for diabetes management is to restore seamless glucose control, thus avoiding the dangerous side effects of hypo- and hyperglycemia,” said Sumita PennathurPhD, Professor in the Department of Mechanical Engineering at UC Santa Barbara.
Research presentation details:
- Michael L. StitzelPhD will present his study Deciphering Longitudinal Cell Type-Specific Defects in Diabetes Pathogenesis during the symposium, 2022 Pathway to Stop Diabetes on Friday, June 3 10:10-10:20 am CT.
- Sumita PennathurPhD will present her study Untethering Diabetes through Innovative Engineering during the symposium, 2022 Pathway to Stop Diabetes on Friday, June 3 10:20-10:30 am CT.
For more information, please contact the ADA Scientific Sessions media team onsite at the Ernest N. Morial Convention Center from June 3–7 by phone at 504-670-4902, or by email at [email protected].
About the ADA’s scientific sessions
the ADA’s 82nd Scientific Sessions, the world’s largest scientific meeting focused on diabetes research, prevention, and care, will be a hybrid event held June 3–7, 2022 at the Ernest N. Morial Convention Center in New Orleans, LA. Leading physicians, scientists, and health care professionals from around the world will unveil cutting-edge research, treatment recommendations, and advances toward a cure for diabetes. We are eager to get back to safely participating in person and networking with colleagues while hearing the latest scientific advances and groundbreaking research presentations. Learn more and register at scientificsessions.diabetes.org and join the Scientific Sessions conversation on social media using #ADA2022.
About the American Diabetes Association
The American Diabetes Association (ADA) is the nation’s leading voluntary health organization fighting to bend the curve on the diabetes epidemic and help people living with diabetes thrive. For 81 years, the ADA has driven discovery and research to treat, manage, and prevent diabetes while working relentlessly for a cure. Through advocacy, program development, and education we aim to improve the quality of life for the over 133 million Americans living with diabetes or prediabetes. Diabetes has brought us together, what we do next will make us Connected for Life. To learn more or to get involved, visit us at diabetes.org or call 1-800-DIABETES (1-800-342-2383). Join the fight with us on Facebook (American Diabetes Association), Spanish Facebook (Asociación Americana de la Diabetes), LinkedIn (American Diabetes Association), Twitter (@AmDiabetesAssn), and Instagram (@AmDiabetesAssn).
Contact: Daisy Diaz504-670-4902
SOURCE American Diabetes Association